Overview
What it is.
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme expressed in fat tissue that has become a research target in metabolic-regulation studies. Unlike most compounds in this catalog it is orally studied in preclinical models, though it is sold here in reconstitutable vial form for research consistency.
Research Areas
- Studied for its potential role in NNMT-pathway inhibition in adipose tissue
- Studied in preclinical models for a role in fat-cell metabolic regulation
- Studied for its interaction with cellular NAD+ and energy-metabolism pathways
Batch & Testing
Proof, not promises.
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Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme highly expressed in fat tissue. It's chemically distinct from the peptides that make up most of this catalog, developed as an orally bioavailable research tool for probing NNMT's role in adipocyte metabolism.
NNMT methylates nicotinamide using a methyl group borrowed from SAM (S-adenosylmethionine), a reaction that competes with pathways cells use for their own methylation and NAD+ metabolism. By inhibiting NNMT, 5-Amino-1MQ is studied for how blocking that competition affects fat-cell energy handling and NAD+ availability.
Use Cases Explored
- Studied for NNMT-pathway inhibition in adipose tissue
- Studied in preclinical models for fat-cell metabolic regulation
- Studied for interaction with cellular NAD+ and energy-metabolism pathways
- Studied as a chemical-probe compound rather than a characterized therapeutic candidate
The Evidence
Preclinical animal models
Most published data comes from rodent studies examining NNMT inhibition's effect on adipose tissue and metabolic markers — there is no meaningful human clinical trial record for this specific compound.
Mechanistic / in vitro studies
Cell-culture work has characterized NNMT's biochemistry and 5-Amino-1MQ's inhibitory activity, but translating those findings to intact organisms remains an open research question.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
5-Amino-1MQ FAQ
Questions
5-Amino-1MQ FAQ
What is 5-Amino-1MQ studied for?+
5-Amino-1MQ is studied for its inhibition of NNMT, an enzyme expressed in fat tissue, examined in preclinical models for a possible role in fat-cell metabolic regulation.
Is 5-Amino-1MQ a peptide?+
No — it's a small-molecule inhibitor, not a peptide. It's included here because it's frequently studied alongside metabolic peptide research protocols.
Why is 5-Amino-1MQ sold in reconstitutable vial form if it's studied orally in preclinical models?+
Selling it in the same lyophilized vial format as the rest of the catalog keeps reconstitution and handling consistent across a researcher's protocol, even though preclinical literature on this compound has largely used oral dosing routes.
How should 5-Amino-1MQ be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
Metabolic
5-Amino-1MQ
1-methylnicotinamide inhibitor
A small-molecule NNMT inhibitor studied for a role in fat-cell metabolism research.
Size
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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