Overview
What it is.
AOD-9604 is a small fragment of the human growth hormone molecule, isolated for the segment researchers believed was responsible for fat-metabolism effects without triggering GH's broader growth-signaling activity.
Research Areas
- Studied for its potential role in fat-metabolism research
- Studied as an isolated fragment of the growth hormone molecule
- Studied in early-stage metabolic research trials
Batch & Testing
Proof, not promises.
COA ships with every order
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Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
AOD-9604 is a 16-amino-acid fragment of the human growth hormone molecule, engineered to isolate the piece researchers believed was responsible for fat-metabolism (lipolytic) effects, without the broader growth-promoting activity of full-length growth hormone. It was developed by the Australian company Metabolic Pharmaceuticals specifically as an anti-obesity drug candidate.
AOD-9604 corresponds to the C-terminal fragment of human growth hormone (176-191), the region researchers identified as driving GH's effect on fat breakdown in animal models, theoretically without triggering GH's effects on bone and tissue growth or insulin resistance.
Use Cases Explored
- Historical drug-development research into isolated GH-fragment approaches to fat metabolism
- Academic and mechanistic study of lipolytic signaling separate from full GH activity
The Evidence
Early Phase 2 signal (12-week trial)
An earlier, smaller trial reported a modest weight-loss difference versus placebo (2.6 kg vs 0.8 kg) that generated initial optimism about the compound.
Pivotal Phase 2b trial (536 participants, reported 2007)
In the larger, 24-week OPTIONS trial with oral dosing, AOD-9604 failed to produce statistically significant weight loss versus placebo. Development for the obesity indication was terminated, and the company never advanced it to Phase 3 or published the negative results in a peer-reviewed journal.
Honest limits
Some researchers have suggested the oral delivery method — rather than the underlying biology — may explain the failure, since peptides generally degrade in the GI tract, but no large injectable trial was ever run to test that. AOD-9604 has never received FDA approval as a drug for any indication and has no legitimate U.S. compounding pathway.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
AOD-9604 FAQ
Questions
AOD-9604 FAQ
What is AOD-9604 studied for?+
AOD-9604 is studied as an isolated fragment of the growth hormone molecule, examined in early-stage metabolic research for a role in fat-metabolism signaling separate from GH's broader growth-promoting activity.
Is AOD-9604 the same as full-length growth hormone?+
No. It's a small fragment isolated for the segment researchers believed carried GH's fat-metabolism activity, engineered specifically to avoid triggering GH's broader growth-signaling effects.
How should AOD-9604 be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Metabolic
AOD-9604
hGH Fragment 176-191
A growth-hormone fragment studied for a role in fat-metabolism research.
Size
Multi-vial pricing
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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