Overview
What it is.
DSIP was first isolated from rabbit brain tissue and named for an early observation linking it to deep (delta-wave) sleep. Decades of follow-up research have produced a mixed record on human sleep-related effects, making it an ongoing subject of sleep-architecture research.
Research Areas
- Studied for its potential role in sleep-wave-regulation research
- Studied for its potential role in stress-response-signaling research
- Studied with mixed results across decades of research literature
Batch & Testing
Proof, not promises.
COA ships with every order
The Certificate of Analysis for your batch ships in the box with your order. We're publishing the certificate archive here next.
Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
DSIP (Delta Sleep-Inducing Peptide) is a small peptide first isolated from rabbit brain tissue in 1977, named for an early observation that it appeared to promote deep, delta-wave sleep. It's one of the oldest peptides discussed in wellness circles today, but its research record has never resolved into a consistent picture.
DSIP was originally proposed to act on sleep-regulating circuits and stress-hormone pathways, including effects on ACTH and cortisol release. However, no specific receptor for DSIP has ever been conclusively identified, and no DSIP-encoding gene has been confirmed — an unusual gap for a peptide with a decades-long research history, and one that keeps its mechanism genuinely unsettled.
Use Cases Explored
- Studied historically for effects on sleep latency and sleep efficiency in small trials
- Studied for a possible role in delta-wave (slow-wave) sleep architecture
- Studied for interaction with stress-hormone pathways, including ACTH and cortisol
The Evidence
Early small human trials (1980s)
Studies with as few as 6 to 16 participants — including chronic-insomnia patients — reported improved sleep efficiency, shorter sleep latency, and longer sleep duration with IV DSIP versus placebo, without daytime sedation.
Contradicting well-controlled studies
Other well-controlled trials from the same era found no statistically significant hypnotic effect — DSIP did not reliably increase total sleep time or slow-wave sleep compared with placebo, making inconsistency the defining feature of the human research record rather than an edge case.
No confirmed receptor or gene
Despite roughly two decades of active study, researchers have never conclusively identified a DSIP receptor or gene, which is part of why scientific interest declined and few new controlled human trials have been published in the last twenty-plus years.
Conflicting hormonal data
Human studies on DSIP's effect on stress hormones directly conflict — one study found reduced circulating ACTH, another found no effect on CRH-stimulated ACTH and cortisol — underscoring how unresolved the basic pharmacology remains.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
DSIP FAQ
Questions
DSIP FAQ
What is DSIP studied for?+
DSIP is studied for its potential role in sleep-wave-regulation research and stress-response-signaling research, an area with a mixed record across decades of follow-up literature.
Why does DSIP's research record vary so much between studies?+
It was first isolated and named for an early observation linking it to deep, delta-wave sleep in animal models. Follow-up human research has produced inconsistent results, so it remains an honestly unsettled subject of sleep-architecture research rather than a well-established one.
How should DSIP be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Neuro
DSIP
Delta Sleep-Inducing Peptide
An early-discovered peptide studied for a possible role in sleep-regulation research.
Size
Multi-vial pricing
Per-vial pricing, applied automatically. No code needed.
Ships within 24 hours · $20 flat shipping · Free over $200
Pay simply and securely via Zelle or Apple Pay (Apple Cash) — instructions are emailed the moment you order. How payment works →
Satisfaction guarantee — if a batch's documentation doesn't check out, contact support and we'll make it right.
All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
Related
