Overview
What it is.
KPV is a tripeptide fragment of alpha-melanocyte-stimulating hormone, studied mainly for anti-inflammatory activity in gut-related research models.
Research Areas
- Studied for its potential role in anti-inflammatory-signaling research
- Studied in gut-related research models
- Studied as a fragment of alpha-MSH, a broader immune- and pigment-related research target
Batch & Testing
Proof, not promises.
COA ships with every order
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Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
KPV is a tripeptide fragment — lysine-proline-valine — derived from alpha-melanocyte-stimulating hormone (alpha-MSH). It retains alpha-MSH's anti-inflammatory activity without the pigmentation effects, and is studied mainly in gut-inflammation research models.
Unlike full-length alpha-MSH, KPV does not require a functional melanocortin receptor to act — it appears to work intracellularly, inhibiting NF-κB and MAP-kinase inflammatory signaling directly, and is transported into intestinal cells via the PepT1 transporter, which is notably upregulated during intestinal inflammation.
Use Cases Explored
- Studied for a potential role in anti-inflammatory signaling
- Studied in gut-inflammation (colitis) research models
- Studied as a fragment of alpha-MSH, a broader immune- and pigment-related hormone
The Evidence
Rodent colitis models
KPV has reduced disease activity, inflammatory cytokine levels, and tissue-injury scores in both DSS- and TNBS-induced colitis in mice, including when given orally — suggesting gastrointestinal stability that's notable for a peptide, though this is animal, not human, evidence.
Mechanistic cell-culture studies
Studies in human gut and bronchial epithelial cell lines have identified how KPV blocks NF-κB signaling at a molecular level (competitively blocking a nuclear-import step), providing a plausible mechanism for the effects seen in animal models.
Human clinical trial data — none completed
No completed human randomized controlled trial has tested KPV as a standalone treatment; the evidence base remains entirely preclinical (rodent models and cultured human cells), and it is not approved as a drug for any indication.
2026 regulatory developments
KPV-related substances received a favorable Pharmacy Compounding Advisory Committee recommendation in July 2026 for possible future 503A bulks-list inclusion, but that is an advisory recommendation, not FDA authorization, and final rulemaking remains pending.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
KPV FAQ
Questions
KPV FAQ
What is KPV studied for?+
KPV is studied for its potential role in anti-inflammatory-signaling research, mainly in gut-related research models, as a fragment of the broader alpha-MSH immune- and pigment-related research target.
What is KPV derived from?+
It's a tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH), isolated for the segment researchers associate with anti-inflammatory activity.
How should KPV be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Neuro
KPV
Lysine-Proline-Valine
A small fragment of alpha-MSH studied for anti-inflammatory-signaling research.
Size
Multi-vial pricing
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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