Overview
What it is.
Larazotide is a peptide designed to tighten the junctions between cells lining the gut, studied specifically in the context of intestinal-permeability research. It has one of the deeper formal Phase 3 research records in this category.
Research Areas
- Studied in clinical trials for its potential role in intestinal-barrier (tight-junction) function research
- Studied specifically in research populations with defined gut-permeability-related profiles
- Studied as an orally administered, locally acting research compound
Batch & Testing
Proof, not promises.
COA ships with every order
The Certificate of Analysis for your batch ships in the box with your order. We're publishing the certificate archive here next.
Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
Larazotide (also studied as larazotide acetate, or INN-202) is a peptide designed to tighten the junctions between cells lining the gut wall, studied specifically in the context of intestinal permeability. Unlike most peptides on this page, it has gone through formal Phase 3 pharmaceutical trials — but it remains an investigational drug with no approval.
Larazotide acts locally within the gut, where it's studied for helping regulate the tight junctions between intestinal epithelial cells — junctions that open abnormally in response to gluten exposure in people with celiac disease, a process tied to the persistent gut-permeability symptoms that a gluten-free diet alone doesn't always resolve.
Use Cases Explored
- Studied in clinical trials for a potential role in intestinal tight-junction function
- Studied specifically in populations with persistent celiac-disease-related symptoms
- Studied as an orally administered, locally acting investigational peptide
The Evidence
Phase 2b trial — positive primary endpoint
A Phase 2b trial in 342 patients was, at the time, the only celiac-disease drug candidate to successfully meet its primary efficacy endpoint with statistical significance, which supported advancement into Phase 3 development.
Phase 3 trial (CedLara) — discontinued for futility
The subsequent Phase 3 trial (targeting roughly 600 patients) was stopped early after an interim analysis found the sample size needed to reach a statistically meaningful result was too large to justify continuing — the trial did not produce positive, definitive Phase 3 results.
Post-discontinuation status
Following discontinuation, the trial sponsor stated it would continue analyzing existing data to see whether specific symptom subgroups might still benefit, but no completed, successful Phase 3 program or FDA approval has followed.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
Larazotide FAQ
Questions
Larazotide FAQ
What is Larazotide studied for?+
Larazotide is studied in clinical trials for its potential role in intestinal-barrier (tight-junction) function research, in populations with defined gut-permeability-related profiles, as an orally administered, locally acting research compound.
Why does Larazotide have a deeper clinical research record than most compounds here?+
It has gone through formal Phase 3 clinical trial programs specifically for intestinal-permeability research — one of the deeper formal research records in this catalog, which is why researchers treat it as a reference compound in gut-barrier studies.
How should Larazotide be handled and stored?+
It ships as a lyophilized powder in a single 10 mg size. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Neuro
Larazotide
Larazotide acetate
A peptide studied in formal clinical research for intestinal-barrier (gut-permeability) function.
Size
Multi-vial pricing
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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