Overview
What it is.
Epithalon is a synthetic four-amino-acid peptide developed from pineal-gland research, studied mainly in the context of cellular aging and telomerase-related signaling. Most supporting research comes from animal-model studies.
Research Areas
- Studied for its potential role in telomerase-related cellular signaling
- Studied in animal models for a potential role in lifespan-related-marker research
- Studied for its potential role in pineal-gland and circadian-signaling research
Batch & Testing
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Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
Epithalon (also spelled Epitalon) is a short, four-amino-acid synthetic peptide developed by Russian researchers as a simplified analog of a natural pineal-gland extract. It's studied mainly in the context of cellular aging, telomerase activity, and pineal/circadian signaling.
In cultured human cells, Epithalon has been reported to induce expression of the telomerase catalytic subunit and extend the number of times treated fibroblasts can divide before senescence — pointing to a possible role in telomere-related cellular aging pathways, though the human-level significance of that mechanism remains unestablished.
Use Cases Explored
- Studied for a potential role in telomerase-related cellular signaling
- Studied in animal models for lifespan-related markers
- Studied for a potential role in pineal-gland and circadian-related signaling
The Evidence
In vitro human fibroblast studies (Khavinson lab, 2003–2004)
Foundational cell-culture studies from the peptide's original Russian research group reported that Epithalon induced telomerase activity and extended fibroblast lifespan in culture, but the original papers report largely qualitative findings without full statistical detail.
Independent replication (2025, Brunel University London)
A 2025 study by a research group unaffiliated with the original developers reported that Epithalon increased telomere length in human cell lines — one of the first independent replications of the mechanism, though still a cell-culture (not human-body) result.
Animal lifespan studies
Separate animal studies report extended lifespan in flies and rats and reduced age-related chromosomal abnormalities in mice, but rodent lifespan extension does not reliably predict human outcomes.
Human clinical trial data — largely absent independently
No Phase 2 or Phase 3 controlled human efficacy trial has been published in an internationally indexed peer-reviewed journal. Human outcome claims (telomere length, mortality) trace almost entirely back to the original Russian research group and have not been independently replicated in controlled human trials.
Specifications
The essentials.
Specifications
The essentials.
- Vial Capacity
- 3 ml glass vial
- Form
- Lyophilized powder
- Solubility
- Reconstitute with bacteriostatic water
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf Life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
Cellular & Longevity
Epithalon
Epitalon
A short synthetic peptide studied in cellular-aging research for a role tied to telomerase signaling.
Size
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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