Overview
What it is.
FOXO4-DRI is a designed peptide that interferes with the interaction between FOXO4 and p53 inside senescent (aging) cells, a mechanism studied in senolytic research for its role in triggering the selective clearance of senescent cells in animal models.
Research Areas
- Studied in animal models for its role in disrupting the FOXO4-p53 senescent-cell survival interaction
- Studied as a senolytic research compound for selective senescent-cell clearance
- Studied for downstream effects on tissue-function markers in aged research models
Batch & Testing
Proof, not promises.
COA ships with every order
The Certificate of Analysis for your batch ships in the box with your order. We're publishing the certificate archive here next.
Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
FOXO4-DRI is a designed peptide that interferes with a specific protein-protein interaction inside senescent (aging) cells. It's a synthetic research tool built to disrupt the FOXO4-p53 interaction that helps senescent cells resist programmed cell death.
Senescent cells accumulate with age and are studied for contributing to tissue dysfunction; FOXO4-DRI is examined for disrupting the FOXO4-p53 survival interaction specifically inside those cells, which in animal models has been studied for triggering their selective clearance without affecting healthy cells.
Use Cases Explored
- Studied in animal models for disrupting the FOXO4-p53 senescent-cell survival interaction
- Studied as a senolytic research compound for selective senescent-cell clearance
- Studied for downstream effects on tissue-function markers in aged research models
The Evidence
Animal models only
The foundational research on FOXO4-DRI's senolytic effect comes from mouse studies; there is no published human clinical trial data for this specific compound.
Early-stage, single-mechanism research
As a designed peptide targeting one specific protein interaction, its research base is narrower and newer than broadly studied senescence compounds — findings should be treated as preliminary.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
FOXO4-DRI FAQ
Questions
FOXO4-DRI FAQ
What is FOXO4-DRI studied for?+
FOXO4-DRI is studied in animal models as a senolytic research compound, examined for disrupting a survival interaction inside senescent (aging) cells and its downstream effects on tissue-function markers.
What does 'senolytic' mean in the context of FOXO4-DRI research?+
It refers to research into selectively clearing senescent cells from tissue. FOXO4-DRI is studied for interfering with the FOXO4-p53 interaction that helps senescent cells survive, which researchers examine for triggering their clearance in animal models.
How should FOXO4-DRI be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Cellular & Longevity
FOXO4-DRI
FOXO4-p53 interfering peptide
A senolytic research peptide studied for disrupting a senescent-cell survival pathway.
Size
Multi-vial pricing
Per-vial pricing, applied automatically. No code needed.
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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