Overview
What it is.
IGF-1 LR3 is a laboratory-modified analog of insulin-like growth factor 1, engineered with a longer half-life than the endogenous molecule. Because IGF-1 signaling is one of the most potent growth-promoting pathways in the body, it is a closely studied compound in muscle-tissue and growth-factor research.
Research Areas
- Studied for its potential role in muscle-tissue growth signaling
- Studied for its interaction with insulin and glucose-regulation pathways
- Studied for its interaction with growth-factor signaling pathways more broadly
Batch & Testing
Proof, not promises.
COA ships with every order
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Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
IGF-1 LR3 is a laboratory-modified version of insulin-like growth factor 1 (IGF-1) — the hormone GH itself works through — engineered with a longer half-life and reduced binding to the proteins that normally regulate natural IGF-1's activity. That modification is also exactly what makes it a more serious research subject for safety concerns than most peptides on this page.
IGF-1 LR3 binds the IGF-1 receptor directly, bypassing the pituitary GH-release step altogether. Because natural IGF-1 is normally kept in check by binding proteins, LR3's engineered resistance to those binding proteins means it stays active in the body longer and at higher effective levels than the body's own IGF-1 signaling is designed to sustain.
Use Cases Explored
- Studied for its potential role in muscle-tissue growth signaling
- Studied for its interaction with insulin and glucose regulation pathways
- Studied, separately, for its interaction with growth-factor pathways implicated in cancer-cell proliferation
The Evidence
Direct human trial data on IGF-1 LR3 itself is minimal
There is very little dedicated clinical research on the modified LR3 molecule specifically — most of what's cited about it is extrapolated from natural IGF-1 biology rather than from LR3-specific human trials, since it has never gone through a drug-development program.
Elevated natural IGF-1 is consistently linked to cancer risk in large studies
A pooled analysis of 17 prospective studies (over 4,700 breast-cancer cases) and separate meta-analyses found higher circulating IGF-1 associated with increased risk of prostate, colorectal, and premenopausal breast cancer; acromegaly, a condition of chronically elevated GH/IGF-1, is independently associated with higher cancer risk.
LR3's engineering plausibly amplifies, not reduces, that concern
Because LR3 is specifically designed to resist the body's own IGF-1 regulatory proteins and last longer than natural IGF-1, researchers reasonably flag that any cancer-risk signal tied to elevated natural IGF-1 would apply at least as strongly to sustained LR3 exposure — though this remains a mechanistic and epidemiological inference, not a dedicated LR3 outcome study.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
IGF-1 LR3 FAQ
Questions
IGF-1 LR3 FAQ
What is IGF-1 LR3 studied for?+
IGF-1 LR3 is studied as a long-acting analog of insulin-like growth factor 1, examined for its interaction with muscle-tissue growth signaling and its crosstalk with insulin and glucose-regulation pathways.
What does the 'LR3' modification actually change?+
The long-arginine-3 substitution reduces the molecule's binding to IGF-binding proteins compared with native IGF-1, which is studied for extending its circulating half-life and signaling window in research models.
How should IGF-1 LR3 be handled and stored, given the small 0.1 mg size?+
It ships as a lyophilized powder and is reconstituted with bacteriostatic water like the rest of the catalog. Refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Growth Hormone
IGF-1 LR3
Long-arginine-3 IGF-1
A modified, long-acting analog of a potent growth factor, studied for muscle-tissue signaling.
Size
Multi-vial pricing
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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