Overview
What it is.
PNC-27 is a synthetic peptide containing a p53-derived sequence, studied in cellular research for a distinctive mechanism — binding MDM2 protein expressed on cancer-cell membranes and triggering membrane disruption specific to transformed cells in laboratory models.
Research Areas
- Studied in cellular models for its interaction with membrane-expressed MDM2 protein
- Studied for a cancer-cell-selective membrane-disruption mechanism distinct from normal-cell effects
- Studied as part of p53-pathway cellular research
Batch & Testing
Proof, not promises.
COA ships with every order
The Certificate of Analysis for your batch ships in the box with your order. We're publishing the certificate archive here next.
Research Deep-Dive
How it works.
Research Deep-Dive
How it works.
PNC-27 is a synthetic peptide containing a p53-derived sequence, studied in cellular research for a distinctive mechanism: binding MDM2 protein expressed on the surface of cancer-cell membranes and triggering membrane disruption specific to those transformed cells.
Unlike growth-signaling peptides that activate a receptor cascade, PNC-27 is studied for physically inserting into and disrupting the membrane of cells that express MDM2 on their surface — a feature associated with cancer cells but largely absent from healthy cells, which is the basis for its selectivity in lab models.
Use Cases Explored
- Studied in cellular models for its interaction with membrane-expressed MDM2 protein
- Studied for a cancer-cell-selective membrane-disruption mechanism
- Studied as part of p53-pathway cellular research
The Evidence
In vitro cellular research
PNC-27's membrane-disrupting, cancer-cell-selective activity has been documented primarily in cell-culture studies across various cancer-cell lines; there is no published human clinical trial data.
Preclinical animal studies
A smaller number of animal studies have examined tumor-growth effects, but the overall research base remains preclinical and should be treated as early-stage.
Specifications
The essentials.
Specifications
The essentials.
- Form
- Lyophilized powder
- Storage
- Store in a cool, dry place. Refrigerate at 2–8°C after reconstitution
- Shelf life
- 24 months lyophilized; 4–6 weeks refrigerated after reconstitution
- Solubility
- Reconstitute with bacteriostatic water
- Vial capacity
- 3 ml glass vial
Questions
PNC-27 FAQ
Questions
PNC-27 FAQ
What is PNC-27 studied for?+
PNC-27 is studied in cellular models for its interaction with MDM2 protein expressed on cancer-cell membranes, examined for a membrane-disruption mechanism that appears specific to transformed cells in laboratory models.
How does PNC-27's mechanism differ from typical growth-signaling peptides?+
Rather than engaging a receptor to trigger a signaling cascade, PNC-27 is studied for a direct, p53-derived membrane-disrupting interaction with cancer-cell-expressed MDM2 — a mechanistically distinct research subject from GH- or repair-pathway peptides.
How should PNC-27 be handled and stored?+
It ships as a lyophilized powder. Reconstitute with bacteriostatic water and refrigerate at 2–8°C after mixing — good for roughly 4–6 weeks refrigerated, or up to 24 months unreconstituted in a cool, dry place.
What testing does this batch undergo?+
Every batch is HPLC tested for purity and identity, plus sterility and endotoxin screening, before release. The Certificate of Analysis for that lot ships with your order.
Cellular & Longevity
PNC-27
p53-MDM2 interfering peptide
A designed peptide studied in cellular research for a membrane-disrupting effect on cancer cells.
Size
Multi-vial pricing
Per-vial pricing, applied automatically. No code needed.
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All products sold by One Tap Peptides are intended for laboratory research use only. Not for human consumption. Not intended for animal use. Not intended for diagnostic or therapeutic purposes.
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